Mouneimne Lab

The general interest of the lab is to explore different mechanisms by which the architecture of the actin cytoskeleton influences cellular behavior. We are focused on investigating how distinct actin cytoskeletal remodeling programs regulate the invasive behavior of cancer cells and how these programs are influenced by the cellular microenvironment. We follow an interdisciplinary approach, which includes: in vitro structural and biochemical analyses; functional analyses using tissue culture models, 3D organotypic cultures, and in vivo mouse models; bioinformatic and histological analyses of patient samples.

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